Pedestrians cross a street in front of the Tokyo Stock Exchange, operated by Japan Exchange Group, in Tokyo, Japan.

Toru Hanai | Bloomberg | Getty Images

Shares in Asia-Pacific were mixed on Tuesday as investors weigh the impact of monetary policy and economic uncertainty.

Japan and South Korea’s markets resumed trading after a holiday on Monday. The Nikkei 225 dropped around 2% and the Topix lost 1.4%. In South Korea, the Kospi fell 2.26% and the Kosdaq shed 3%.

Taiwan and Malaysia markets also return to trade Tuesday.

In Australia, the S&P/ASX 200 was 0.15% higher. MSCI’s broadest index of Asia-Pacific shares outside Japan dipped 0.36%.

“Equities continue to sell off as the impact of tighter monetary policy spooks investors,” ANZ Research analysts wrote in a note Tuesday.

Overnight on Wall Street, the Nasdaq Composite closed at its lowest since July 2020, down 1.04% at 10,542.10, dragged lower by a slump in semiconductor stocks.

The S&P 500 also slipped 0.75% to 3,612.39, while the Dow Jones Industrial Average shed 93.91 points, or 0.32%, to close at 29,202.88.

— CNBC’s Carmen Reinicke and Alex Harring contributed to this report.